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Allelic imbalance was noted at several scattered heterozygous loci in K562, LAMA 84, SAM 1, TF 1 and HEL cells, which are all erythroid cell lines; the absence of amplification bias involving the smaller alleles at these loci suggestschristian louboutin outlet ukthat the allelic imbalance reflects an unequal dosage of chromosome 20. Eight cell lines (including CMK and U937, shown in Figure 1) showed amplification of only one allele at multiple adjacent loci, including 19 loci mapping to the CDR defined by D20S174 and D20S481 (see Figure 2). This phenomenoncheap timberland boots ukis most readily explained by the presence of only one chromosome 20 homologue (the presence of two bands at D20S481 in MOLM 1 and at D20S465 in U937 is likely a PCR artifact, as numerous contiguous markers proximal or distal to these loci were found to be homozygous).qq0914

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